“The thing that got me started on the science that I've been building now for about 20 years or so was the question of okay, if mathematical equations can't make progress in understanding complex phenomena in the natural world, how might we make progress?”
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Well, the first thing to say is that we've worked hard to maintain compatibility, so that any program written with an earlier version of Mathematica can run without change in 3.0, and any notebook can be converted.
Stephen Wolfram 
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So the thing I realized rather gradually - I must say starting about 20 years ago now that we know about computers and things - there's a possibility of a more general basis for rules to describe nature.
Stephen Wolfram 
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There are a few very small incompatible changes - I really doubt most people will ever run into them.
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